FDA has recently released several updates – including new and updated guidance documents, technical amendments, and policy clarifications – that may be relevant to research oversight committees (such as IRBs and IACUCs), investigators, and research organizations. To help research professionals stay informed, HRP has compiled the following summary highlighting updates released between December 1, 2025 through January 27, 2026, that may affect research oversight, study design, and regulatory responsibilities. In keeping with our focus on Helping Research Professionals, this resource is intended to offer practical context and useful reference points as FDA guidelines continue to evolve.
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