On November 21st OHRP announced two exceptions from the required use of a single IRB to review cooperative research that is subject to the HHS regulations for the protection of human subjects.

The OHRP announcement can be found here: https://www.hhs.gov/ohrp/exception-determination-required-sirb-use-certain-research.html, and the Federal Register notice here: https://www.federalregister.gov/documents/2019/11/22/2019-25358/hhs-policy-for-the-protection-of-human-research-subjects.

These exceptions are intended to address concerns expressed by COGR, AAMC, and others about the single IRB requirement applying to research subject to the revised Common Rule that was approved prior to the January 20, 2020 compliance date (for the cooperative research provisions at 45 CFR 46.114(b)).  Importantly, the exceptions only apply to research conducted or supported by HHS.  As noted in the Federal Register:

The revised Common Rule provides that the agency conducting or supporting cooperative research may except the research from the single IRB mandate. To do so, the agency must both determine and document that using a single IRB is not appropriate in the particular context. See 45 CFR 46.114(b)(2).

Non-HHS departments and agencies that have signed on to the Common Rule such as Dept. of Defense, Dept. of Education, Dept. of Veterans Affairs, and the National Science Foundation would have to issue their own exceptions to exclude pre-existing research subject to the revised Common Rule from the single IRB mandate.  A full list of departments and agencies that comply with the Common Rule can be found here: https://www.hhs.gov/ohrp/regulations-and-policy/regulations/common-rule/index.html.  Please note that the Dept. of Justice, including the National Institute of Justice, is not currently a signatory thus the single IRB mandate is not applicable unless the research is also supported by a Common Rule Agency.